Women who have preeclampsias, a type of excessively high blood pressure when pregnant, are five times more likely than women who have normal blood pressure during the pregnancy to develop end-stage kidney diseases later in life, according to a Swedish report.
The risk of heart attacks or heart failure years later, as well as previous research, has long been related to Preeclampsia, and some previous studies suggest that high blood pressure may also be a cause for the increased likelihood of women having advanced renal disorders than men.
Researchers examined data on nearly 2.67 million births between 1982 and 2012 among 1.37 million women for the current study. In total, 67 273 women developed preeclampsia, or 4.9 percent, and 410 women developed kidney disease at the end of the stage.
The study found that women with preeclampsia had a greater than seven-fold chance of developing kidney disease at the end of the stage than women with no preeclampsie.
The lead study author Ali Khashan, Public Health Researcher, University College Cork, Ireland, said:’ This study has shown Pre-eclampsia is a sex specific, independent risk factor for the further development of end stage kidney disease.’
The overall risk of renal disease at the end of phase, however, remains low and women with preeclampsia history should not be overly concerned,” said Khashan by email.
Pre-eclampsias are more than nine times more likely to develop end-stage kidney disease in women before pregnancy-before the halfway mark-than in women with a normal blood pressure.
The challenge with preeclampsia, particularly when women are safe and have uncomplicated pregnancies, is that they often have no symptoms until they have a life-threatening problem.
Kidney failure is most often caused by diabetes and high blood pressure, also called end-stage kidney diseases (EKD). Autoimmune or genetic disorders and urinary chronic tract problems can also be caused.
Patients need organ transplantation and dialysis for kidney failure.
Also researchers have identified other factors that may influence maternal health such as age, education and pregnancies, such as current renal disease and cardiovascular disease, which have persisted as a correlation between pre-eclampsia and kidney failure in the study.
Pre-eclampsia women in the study were on average older and had a lower level of body mass (BMI).
14.2 percent were overweight and 4.9 percent were obese among women without preeclampsia during their first pregnancy. 20.1 percent were overweight and 11.7 percent were obese among women with preeclampsia during their first pregnancy.
The study was not a controlled experiment to test whether preeclampsia could later in life lead to renal failure.
It can lead to both pre-eclampsia and renal failure in the line, researchers note in PLoS Medicine, risk factors like obesity, high blood pressure, and diabetes. Many women with preeclampsia may also have had issues with the kidneys at that time that have not been diagnosed.
“The findings mentioned were independent of these causes,” Khashan said. “We have taken maternal obesity and complications like diabetes into account. “The possible mediators between preeclampsia and end stage renal disease can not be ruled out in its entirety, however.”
Source : Reuters
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